INTRODUCTION: Carcinosarcoma is a very aggressive neoplasm. The use of tyrosine kinase inhibitors has resulted in successful treatment of KIT-positive neoplasms. Consequently, c-kit expression may have significant clinical implications for this tumor. The purpose of the present study was to assess c-kit expression in the carcinomatous and sarcomatous component of carcinosarcoma and to identify if KIT represents a therapeutic target for treatment of this neoplasm.
METHODS: Immunohistochemical staining for c-kit was performed on paraffin-embedded tissue blocks of 20 uterine specimens with carcinosarcoma.
RESULTS: In the stromal component of carcinosarcoma, no immunohistochemically c-kit stained cells were observed and in the epithelial component, c-kit staining was present in 9 cases.
DISCUSSION AND CONCLUSION: The results seem to suggest that c-kit probably plays no major role in the carcinogenesis of the majority of these tumors. Further studies of c-kit expression in larger series of carcinosarcomas must be studied in order to clarify the controversial issues.

INTRODUCTION: Management of uterine cervical polyps is a common debate in clinical practice. Ethical concerns complicate decision making as well as designing randomized or prospective studies. Thus, clinical evidence can be gathered from retrospective studies. Possibility of malignant transformation is also a concern in assessment and management of pre- and post-menopausal patients. In this study we aimed to identify if a difference exist in between these groups, and discuss our results with the previously reported.
METHODS: We evaluated results of 245 patients retrospectively. Totally 270 polyps were detected. Pathological results of polyps were compared
according to menopausal status and symptoms. Fisher’s Exact Test and Fisher-Freeman-Halton Test were used in statistical analysis. Statistical significance is considered where p<0.05 and p<0.01.
RESULTS: There was no invasive disease. Cervical intraepithelial neoplasia type 1 was seen in one postmenopausal patient. Polyps were asymptomatic in 39.6% (n=97) of the cases and coincide with abnormal uterine bleeding (AUB) in 53.9% (n=132), and missed abortus in 6.5% (n=16). Patients with polyps significantly tend to have complaint of abnormal uterine bleeding compared to other symptoms.
DISCUSSION AND CONCLUSION: Routine cervical polypectomy is not necessary. Cytology and utilization of colposcopy should be considered prior to polypectomy, as well
as assessment of clinical and menopausal status.

INTRODUCTION: Adenomyosis is a entity characterized by the presence of endometrial glands and stroma embedded within the myometrium without apparent contact with the endo-myometrial junction. As the diagnosis of adenomyosis is based on histological examination, the condition is best described in women at the time of hysterectomy.
METHODS: We evaluated results of 109 hysterectomized patients retrospectively. Age, parity, menopausal status and indication of hysterectomy
were compared between adenomyosis positive and negative patients according to histological findings. P value under 0.05 was considered statistically significant.
RESULTS: The mean of age patients with adenomyosis were 55. Parity and abnormal uterine bleeding were associated factors with adenomyosis (p<0.05).
DISCUSSION AND CONCLUSION: Our study demonstrated that the prevalence of adenomyosis at hysterectomy was 29.4%. Adenomyosis is more frequent among women reporting abnormal uterine bleeding and with high parity

Increasing rate of ceseraen delivery causes increasing rate in the complications of this procedure. One of the complications of cesarean section
is cesarean scar pregnancy (CSP), which is a life threatining condition if not diagnosed early.

Calcinosis cutis is an uncommon entity defined as the deposition of amorphous calcium and phosphate salts under epidermis. Idiopathic calcinosis cutis occurs in the absence of any metabolic disorder or tissue damage. A 40-year-old multiparous female presented with vulvar nodular masses with discomfort during intercourse only. Physical examination revealed a yellowish colored non-tender, pedunculated nodules measuring approximately 3×1 cm in the left side of vulva. The mass localized between labia minora and labia majora was solid, surfaced with the white pigmentation, irregular, fixed and in sessile nature. Laboratory evaluation revealed normal serum calcium and phosphorus levels and all other laboratory values were within normal reference ranges. Total surgical excision of the mass was performed under general anesthesia.
The histopathological diagnosis revealed a calcinosis cutis of the vulva and no recurrence was detected 12 months after the initial treatment.

INTRODUCTION: The aim of the study was to determine the effect of pregestational body mass index (BMI) on prenatal and neonatal outcomes.
METHODS: The study is a descriptive and correlational study. It was conducted on 370 postpartum women who had delivered in the medical
faculty hospital at postpartum ward in Istanbul. Data were gathered via structured interview form by the researchers. Mann-Whitney U test, t-test, Anova test and Pearson correlation analysis were run for statistical evaluation.
RESULTS: Mean age was 29.18±5.43 (min: 18- max: 44), mean weight before conception was 61.58±10.66 kg (min: 42-max: 120), mean BMI value
was 28.92±1.40 (min: 18-max: 45) mean weight gained during pregnancy was calculated as 15.68±5.09 kg (min: 1-max: 33). No statistically significant difference was found between pre gestational BMI value and age, level of education, economic
status, gravidity, gestational week, number of previous miscarriages and stillbirths, smoking or drug use, any complaints about pregnancy, prenatal counseling, receiving prenatal care, birth weight and APGAR score. Pregestational BMI values were found to be statistically significant compared to diabetes and hypertensive disorder, methods of delivery and weight gain during pregnancy. Pregestational BMI values and weight gain during pregnancy were found to be statistically different compared to age, interval between subsequent pregnancies and chronic diseases.
DISCUSSION AND CONCLUSION: In preconceptional care, pregestational obesity must be taken into account. Obese women should be pregnant after lose of weight. Weight gain is important to follow regularly during pregnancy. Women should be trained related to nutrition, exercise, and weight control before pregnancy and during pregnancy. According to the study, pregestational obesity and control of weight gain during pregnancy is important outcomes for prenatal and neonatal outcomes.

Classical triad of DiGeorge Syndrome (DGS), where more than %90 of patients are detected by 22q11 deletion, is formed by congenital heart diseases, large vascular anomalies, palatal incapacity, and hypocalcemia. Hypoplasia of timus, speaking and nutrition problems, and mental retardation are other frequently observed signs. Apart from these, several different phenotypic characteristics are identified

Neonatal hydrometrocolpos is a rare anomaly of female reproductive tract secondary to failure of canalization. Newborn may present with abdominal mass and rarely with hydroureteronephrosis.