E-ISSN 2757-8062
Volume : Issue : Year : 2022

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Zeynep Kamil Medical Journal
Calcium ionophore enhances blastocyst formation, embryo quality and live birth delivery rates in patients with previous IVF failures [Zeynep Kamil Med J]
Zeynep Kamil Med J. Ahead of Print: ZKMJ-14471

Calcium ionophore enhances blastocyst formation, embryo quality and live birth delivery rates in patients with previous IVF failures

Fırat Tülek1, Alper Kahraman2
1Department of Obstetrics and Gynecology, Memorial Atasehir Hospital, Istanbul/Turkey
2Department Of Obstetrics And Gynecology, Haseki Training And Research Hospital, Istanbul/Turkey

INTRODUCTION: Objective: To evaluate the impact of artificial oocyte activation (AOA) with calcium ionophore (A23187) on IVF outcomes of patients with previous history of cycle cancellations due to arrested embryos before formation of day 5 blastocysts.
METHODS: This retrospective study was conducted by evaluating records of patients that admitted for in-vitro fertilization between 2013 and 2021. Patients with previous history of developmental arrest in whole embryo cohort without fertilization failure were included in the study. Cycle outcomes of women with and without AOA were compared.
RESULTS: A total of 347 women were found eligible and included in the study. One-hundred-eighty-five of them were treated with AOA that constituted the study group and 162 women were included in control group. Rate of good quality embryos (65.3% vs. 31.1%; p<0.001), implantation rates (0.33±0.41 vs. 0.22±0.39; p=0.003), clinical pregnancy rates (43.2% vs. 25.3%; p<0.001) and live birth delivery rates (40.5% vs. 21%; p<0.001) were higher in women treated with AOA with calcium ionophore in comparison to controls. Rate of multiple pregnancy was also found higher in calcium ionophore group (5.4% vs. 1.9%; p=0.01). Mean infant birth weights were similar among groups.
DISCUSSION AND CONCLUSION: AOA with A23187 appears to improve progression to blastocyst rates, embryo quality, clinical pregnancy rates and live birth delivery rates in women with a previous history of complete embryo development arrest before formation of day 5 blastocysts.

Keywords: artificial oocyte activation, calcium ionophore, A23187, in-vitro fertilization, live birth rate



Corresponding Author: Fırat Tülek, Türkiye
Manuscript Language: English
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