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Investigating The Changes In Maternal Serum Brain-Derived Neurotrophic Factor Levels In Patients Undergoing Spontaneous Vaginal Delivery
Ayşe Nur Aksoy1, Ilay Gözükara1, Suna Kabil Kucur1, Gonca Batmaz2, Esra Laloğlu3, Elif Bulut41Nenehatun Maternity Hospital, Gynecology Hospital. and the Department of Gynecology, Erzurum, Turkey2Bezmialem Foundation University School of Medicine, Department of Obstetrics and Gynecology, Istanbul, Turkey
3Atatürk University Faculty of Medicine, Department of Biochemistry, Erzurum, Turkey
419 Mayıs University Faculty of Economics and Administrative Sciences, Department of Business, Samsun, Turkey
INTRODUCTION: To reveal the changes in maternal serum brain-derived neurotrophic factor (BDNF) and malondialdehyde (MDA) levels in women undergoing spontaneous vaginal delivery.
METHODS: This prospective study was done in sixty-two patients with term pregnancy undergoing spontaneous vaginal delivery. Maternal blood samples in the latent phase of labor (T1), immediately before clamping the umbilical cord (T2) and 24 hours after birth (T3); and umbilical artery cord blood sample immediately after umbilical cord clamping at delivery were obtained. MDA and BDNF levels in collected blood samples were measured and results were compared using appropriate statistical tests. The relationship between cord blood levels of BDNF with cord blood MDA and maternal serum levels of BDNF with maternal serum MDA was investigated.
RESULTS: Maternal serum BDNF levels (pg/ml) were significantly higher in the blood sample collected at the T3 time point (3729.92 ± 621.68) compared to blood samples collected at T1 (956.75 ± 291.47) and T2 (985.50 ±291.91) time points (P<0.0001, for both). Cord blood
BDNF levels (834.91 ± 235.73) were significantly lower compared to maternal blood samples collected at T1, T2 and T3 time points (P=0.01, P=0.002, P<0.0001; retrospectively). Maternal serum MDA levels (μmol/ml) at T3 time point (6.42 ± 1.70) were found to be lower compared with those of collected blood samples at T1 (8.43 ± 2.67) and T2 (8.80 ± 3.11) time points (P<0.0001, for both).
Also, cord blood MDA levels (9.98 ± 1.70) were higher compared to maternal serum MDA levels collected at T1, T2 and T3 time points (P=0.001, for T2 and P<0.0001, for T1 and T3 time points). A negative association was found between both maternal and cord blood BDNF levels with maternal and cord blood MDA levels, respectively (r= -0.374, P<0.0001; r= -0.310, P=0.014; respectively).
DISCUSSION AND CONCLUSION: Changes in maternal BDNF and MDA levels occur in women undergoing spontaneous vaginal delivery. These changes may be associated with increased maternal oxidative stress during labor
Corresponding Author: Ayşe Nur Aksoy, Türkiye
Manuscript Language: English
