Zeynep Kamil Med J. 2024; 55(1): 29-33 | DOI: 10.14744/zkmj.2023.71084

The role of anti-mullerian hormone in determining ovarian reserve in patients with endometrioma and benign cysts

Ergül Demirçivi¹, Duygu Vardaðlý², Ali Ýsmet Tekirdað³, Özgür Akbayýr³, Ahmet Gülkýlýk³, Beyhan Ömer⁴, Sezai Sahmay^5
1Department of Obstetrics and Gynecology, Istanbul Medeniyet University, Istanbul, Turkey
²Division of Health Service Vocational School, Istanbul Esenyurt University, Istanbul, Turkey
³Department of Obstetrics and Gynecology, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
⁴Department of Biochemistry, Istanbul Universitiy Faculty of Medicine, Istanbul, Turkey
⁵Department of Obstetrics and Gynecology, Istanbul Universitiy Cerrahpasa Faculty of Medicine, Istanbul, Turkey

INTRODUCTION: Our aim was to determine the effects of endometrioma by itself and its surgery on ovarian reserve via pre- and postoperative serial measurements of Anti-Mullerian Hormone (AMH) in patients with endometrioma and benign cysts.
METHODS: Our study was conducted at an education and research hospital as a prospective controlled clinical trial. Participants were divided according to their diagnosis into endometrioma and non-endometrioma groups. Serial blood samples of the patients for serum AMH levels were collected preoperatively, and postoperatively at the first week, first month, and third month, respectively.
RESULTS: A total of 46 patients (25 for the study and 21 for control groups) were included in the study. The mean age of our patients was 31.8±5.57 in the endometrioma group and 29.38±8.64 in the control group. The AMH value was lower in the endometrioma group, but the difference did not reach statistical significance (p>0.05). However, in the postoperative AMH levels measured at the 1st week, 1st month, and 1st year, the values were significantly higher in the non-endometrioma group compared to the endometrioma group (p<0.05).
DISCUSSION AND CONCLUSION: According to our study, we can conclude that endometrioma surgery affects ovarian reserve significantly and more negatively than benign cystectomies.

Keywords: Anti-mullerian hormone (AMH), benign cyst, endometrioma, ovarian reserve, surgery.

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