Zeynep Kamil Med J. 2014; 45(2): 84-93

Peritoneal Dialysis Solutions

Ebru Yýlmaz¹, Nida Dinçel², Ipek Kaplan Bulut³, Sevgi Mir^3
1Dr. Behcet Uz Child Health and Diseases Pediatric Surgery Eðt. Res. Hospital. Nephrology Clinic
²Ankara Child Health and Diseases Hematology Oncology Eðt. Res. Hospital. Nephrology Clinic
³Ýzmir Ege University Faculty of Medicine Pediatric Nephrology Department

Peritoneal dialysis (PD) is an important kidney replacement therapy for end stage renal disease (ESRD) patients. Patients easily adapt at home based treatment of PD. Standard traditional solutions uses glucose as an osmotic agent. Glucose based dialysis solutions contains high concentrations of glucose. They cause production of glucose degradation products and lactate. They have high
osmolality, and low pH. All these features damage to the peritoneum by fibrosis and neoangiogenesis. Newer PD solutions were produced with alternative buffers and osmotic agents (icodextrin or amino acids). They have a higher pH and causes production
of fewer glucose degradation products. With the usage of newer PD solutions we can achieve better metabolic controls of patients and body compositions. Peritoneal membrane viability increases by their less fibrotic and less inflammatory features of new solutions. But their effect on patient survival is not clearly identified yet. The aim of this review is to describe and to overview the different types of peritoneal dialysissolutions used during PD.

Keywords: chronic renal failure, peritoneal dialysis, peritoneal dialysis solution

---

CITE