Comparison of The Outcomes of ART Treatment Between Patients < 36 And ≥ 36 Years of Age with Low Serum AMH Levels

INTRODUCTION: To compare the outcomes of ART treatment between women < 36 years and ≥ 36 years of age with low serum AMH levels.
METHODS: Patients who underwent intracytoplasmic sperm injection (ICSI) treatment with low AMH levels at our infertility clinic were enrolled into
the study, retrospectively. Patients were divided into two groups as <36 years and ≥ 36 years of age. The outcomes of ART treatment were compared between two groups.
RESULTS: The total numbers of embryos were found significantly higher in women < 36 years of age than in women ≥ 36 years of age with low AMH levels. The total number of top quality embryos on day 1 was lower in women ≥ 36 years of age than in women < 36 years of
age and the difference between two groups showed statistically significance. The biochemical, clinical, and ongoing pregnancy rates of women < 36 years of age were higher than women ≥ 36 years of age; however only the ongoing pregnancy rate showed statistical significant difference. The cycle cancellation rates of women < 36 years and women ≥ 36 years of age were 1.7% and
15.2%, respectively and the difference was found as statistically significant.
DISCUSSION AND CONCLUSION: The higher ongoing pregnancy rates and embryo quality in younger women is an important outcome to encourage the young women with low serum AMH levels for ART treatment option. Age should take into account in the management and information of women with low AMH level in terms of pregnancy rates and characteristics of ART treatment particularly cycle cancellation rates.