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The effect of diabetic ketoacidosis in childhood on heart rate variability: Prospective study
Arzu Gülseren1, Hasan Ağın2, Timur Meşe3, Özlem Nalbantoğlu4, Cem Karadeniz5, Rana İşgüder6, Gökhan Ceylan21Department of Gastroenterology, Hepatology and Nutrition, Kayseri Training and Research Hospital, Kayseri, Türkiye2Department of Pediatric Intensive Care, Dr. Behçet Uz Children’s Hospital, İzmir, Türkiye
3Department of Pediatric Cardiology, Dr. Behçet Uz Children’s Hospital, İzmir, Türkiye
4Department of Pediatric Endocrinology, Dr. Behçet Uz Children’s Hospital, İzmir, Türkiye
5Department of Pediatric Cardiology, Tepecik Training and Research Hospital, İzmir, Türkiye
6Department of Pediatric Rheumatology, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye
INTRODUCTION: The study aims to investigate the changes caused by diabetic ketoacidosis (DKA) on heart rate variability (HRV).
METHODS: This prospective study was conducted at a tertiary referral center. It is investigated patients with DKA under 18 years old between May 2016 and December 2016. 24-h rhythm Holter electrocardiography recorded during DKA and upward 72nd h after ketoacidosis.
RESULTS: A total of 18 patients with DKA were included in the study in the age range of 1 month–18 year. Repeat Holter electrocardiography recording in the patients took place within an average of 4.6±1.1 days. Heart rate change parameters were found to be shorter at the time of DKA. A statistically significant difference was observed between the values of HRV.
DISCUSSION AND CONCLUSION: It is an important factor affecting the development of cardiac autonomic neuropathy at acute blood glucose elevation such as DKA.
Keywords: Cardiac autonomic neuropathy, diabetes mellitus, diabetic ketoacidosis, heart rate variability.
Manuscript Language: English
