E-ISSN 2757-8062
Volume: 53 Issue: 4 Year: 2022

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Calcium ionophore enhances blastocyst formation, embryo quality, and live birth delivery rates in patients with previous IVF failures [Zeynep Kamil Med J]
Zeynep Kamil Med J. 2022; 53(4): 170-175 | DOI: 10.14744/zkmj.2022.14471

Calcium ionophore enhances blastocyst formation, embryo quality, and live birth delivery rates in patients with previous IVF failures

Fırat Tülek1, Alper Kahraman2
1Department of Obstetrics and Gynecology, Memorial Ataşehir Hospital, İstanbul, Türkiye
2Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, İstanbul, Türkiye

INTRODUCTION: The objective of the study was to evaluate the impact of artificial oocyte activation (AOA) with calcium ionophore (A23187) on in vitro fertilization outcomes of patients with previous history of cycle cancellations due to arrested embryos before formation of day 5 blastocysts.
METHODS: This retrospective study was conducted by evaluating records of patients that admitted for in vitro fertilization between 2013 and 2021. Patients with the previous history of developmental arrest in whole embryo cohort without fertilization failure were included in the study. Cycle outcomes of women with and without AOA were compared.
RESULTS: This retrospective study was conducted by evaluating records of patients that admitted for in vitro fertilization between 2013 and 2021. Patients with the previous history of developmental arrest in whole embryo cohort without fertilization failure were included in the study. Cycle outcomes of women with and without AOA were compared.
DISCUSSION AND CONCLUSION: AOA with A23187 appears to improve progression to blastocyst rates, embryo quality, clinical pregnancy rates, and live birth delivery rates in women with a previous history of complete embryo development arrest before formation of day 5 blastocysts.

Keywords: A23187, artificial oocyte activation, calcium ionophore, in vitro fertilization, live birth rate.

Fırat Tülek, Alper Kahraman. Calcium ionophore enhances blastocyst formation, embryo quality, and live birth delivery rates in patients with previous IVF failures. Zeynep Kamil Med J. 2022; 53(4): 170-175

Corresponding Author: Fırat Tülek, Türkiye
Manuscript Language: English
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