E-ISSN 2757-8062
Volume: 52 Issue: 4 Year: 2021

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Serum endocan concentration in women with placenta accreta [Zeynep Kamil Med J]
Zeynep Kamil Med J. 2021; 52(4): 165-169 | DOI: 10.14744/zkmj.2021.15046

Serum endocan concentration in women with placenta accreta

Çiğdem Yayla Abide1, İlter Yenidede1, Çetin Kılıççı1, Evrim Bostancı1, Ahmet Eser1, İsmail Dağ2, Önder Tosun1, Enis Özkaya1
1Department of Obstetrics and Gynecology, University of Health Sciences, Turkey. Zeynep Kamil Maternity and Children’s Training and Research Hospital, İstanbul, Turkey
2Department of Clinical Biochemistry, Eyüp State Hospital, İstanbul, Turkey

INTRODUCTION: Placenta accreta was shown to be associated with abnormal attachment, invasion, and penetration of the chorionic villi to the myometrium. Endocan was shown to have a significant role in the regulation of cell adhesion, inflammation, and tumor progression. The aim of this study was to investigate serum endocan levels in pregnant women with and without placenta accreta.
METHODS: This study was conducted on 27 pregnant women with placenta accreta, 27 pregnant with total placenta previa, and 27 healthy pregnant women matched for gestational age. Maternal levels of serum endocan were measured with the use of an enzyme-linked immunosorbent assay kit.
RESULTS: A significantly lower median level of endocan was detected in the group with placenta invasion compared to the other two groups (132.2 vs. 153.2 and 296.4). The differences among these three groups were statistically significant.
DISCUSSION AND CONCLUSION: These findings suggest a possible protective role of endocan in the pathogenesis of placental invasion. It may be utilized as a biomarker for the detection of placenta accreta during early pregnancy.

Keywords: Abnormal placentation, accreta, endocan, placenta previa, placental invasion.

Çiğdem Yayla Abide, İlter Yenidede, Çetin Kılıççı, Evrim Bostancı, Ahmet Eser, İsmail Dağ, Önder Tosun, Enis Özkaya. Serum endocan concentration in women with placenta accreta. Zeynep Kamil Med J. 2021; 52(4): 165-169

Corresponding Author: Çiğdem Yayla Abide, Türkiye
Manuscript Language: English
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