The Effectiveness of Postcoital Antimicrobial Prophylaxis Low Dose Nitrofurantoin in Uncomplicated Recurrent Urinary Tract İnfections Among Non-Pregnant Premenopausal Women

INTRODUCTION: Recurrent urinary tract infection (RUTI) is an important public health problem in terms of disease management. Most frequently the agent is Escherichia coli. Protection methods include continous and post-coital prophylaxis, latter has similar efficiency with lesser drug dosage. In this study we aimed to investigate the efficiency of post-coital prophylaxis in prevention of RUTI.
METHODS: We retrospectively evaluated premenopausal, non-pregnant, and sexually active adult women whom were suggested to use single dose of 50 mg of nitrofurantion per oral in terms of post-coital prophylaxis for six months along with lifestyle modifications. Data of follow up examination after six months of therapy were also included.
RESULTS: Thirty nine patients were included. One patient couldn’t complete the prophylaxis due to gastrointestinal side effects. Data of thirty eight patients were statistically evaluated. There wasn’t any recurrence of RUTI and success rate was 100%. In terms of follow up examinations, one patient had a recurrent four months after the end of prophylaxis. Overall success rate for twelve months was 97.4%.
DISCUSSION AND CONCLUSION: Post-coital prophylaxis with low dose nitrofurantion was found both effective and safe for treatment of premenopausal, non-pregnant women with RUTI for both six months of treatment and six months of follow up period. This effect should be further evaluated with longitudinal prospective studies.