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Photodynamic Therapy Based Combination Therapy Application for Ovarian Cancer
S. Sibel Erdem1, Vildan Akgul Obeıdın2, Rabia Edibe Parlar3, Ubeydullah Şahin11Medipol International Istanbul University Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey2Restorative and Regenerative Medicine Research Center (REMI), Istanbul, Turkey
3Medipol Istanbul University Institute of Health Sciences Medical Biochemistry Department, Istanbul, Turkey
INTRODUCTION: Cancer is one of the most leading causes of death in Turkey as well as in the world. It is very critical to cure the cancer via targeted therapy that is locally applied and shows minimum side effects for patient’s life quality. Photodynamic therapy (PDT) is a local, photochemistry based treatment, which has minimum side effects. In brief, PDT is a result of a combination of photosensitizer, a drug that is activated by light, light and oxygen that generates free radicals and/or singlet oxygen and starts series of reactions in cell and eventually cause cell death. While light, oxygen and photosensitizer has no cytotoxic effect alone, combination of three starts all photochemical reactions and as a result cytotoxicity is generated in the tissue. Photosensitizer, converting light energy to the chemical energy in the cell, is the most critical component of PDT. One way to improve effectiveness of PDT is to combine it with different
treatment modalities. Cancer and other degenerative diseases involve several pathological mechanisms and require multiple
treatment methods such as combination therapies. A combination therapy targets to bring together current therapies and/
or drugs to act upon different cellular signaling pathways/ cell damage pathways thus activating various mechanisms in the cell increasing the success rate of the treatment. In the light of these information, a new combination therapy, based on PDT
and chemotherapy, has been investigated towards SKOV-3 over cancer cell line. A novel and water-soluble photosensitizer and
a chemotherapy drug called Irinotecan that is been used in clinic were employed. Our results showed that outcome of the combination therapy, which is composed of PDT and chemotherapy, highly depends on the order of the treatment. For instance, when PDT applied first, strong antagonism is observed at certain drug concentrations. On the other hand, synergism is observed using the same drug concentrations yet by only changing the order of the treatment.
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Manuscript Language: English
