E-ISSN 2757-8062
Volume: 53 Issue: 2 Year: 2022

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Can systemic inflammatory markers predict sperm retrieval with the micro-TESE procedure in patients with non-obstructive azoospermia? [Zeynep Kamil Med J]
Zeynep Kamil Med J. Ahead of Print: ZKMJ-46704

Can systemic inflammatory markers predict sperm retrieval with the micro-TESE procedure in patients with non-obstructive azoospermia?

Belgin Devranoglu1, Ali Aras2, GÖKŞEN DERYA REİS KÖSE3, Elif Tozkır1, Pınar Kumru1, Enis Özkaya1, ilhan Sanverdi1, EBRU COGENDEZ1, Nurullah Peker4
1University of Health Sciences, Zeynep Kamil Women and Children Diseases Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey
2University of Health Sciences, Zeynep Kamil Women and Children Diseases Training and Research Hospital, Department of Urology, Istanbul, Turkey
3University of Health Sciences, Zeynep Kamil Women and Children Diseases Training and Research Hospital, Department of Histology and Embryology, Istanbul, Turkey
4Dicle University, Faculty of Medicine, Department of Obstetrics and Gynecology, Diyarbakır, Turkey

INTRODUCTION: We aim to investigate the relationship between the pro-inflammatory markers and sperm retrieval in microdissection testicular sperm extraction(micro-TESE) procedure in patients with non-obstructive azoospermia(NOA).


METHODS: This retrospective study was conducted with 318 patients who applied to our in vitro fertilization(IVF) Unit between April 2017 and December 2020 and underwent micro-TESE for NOA. Patients with (Group1) and without (Group 2) sperm retrieved were compared in terms of age, infertility duration, body mass index(BMI), hormone profile, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-eosinophil ratio (MER), platelet-to-lymphocyte ratio (PLR), and a new marker of eosinophil-to-lymphocyte ratio (ELR).
RESULTS: Sperm retrieval from the micro-TESE procedure was achieved in 183(57.5%) of 318 patients. Testicular tissue biopsies were performed simultaneously in all cases. There was no statistically significant difference between the groups concerning BMI. When the groups were compared regarding the pro-inflammatory markers, while the NLR, MER, and PLR were found to be statistically higher in Group 2 cases; ELR was similar among groups.

DISCUSSION AND CONCLUSION: The MER, NLR, and PLR were determined to be associated with negative micro-TESE results. Particularly PLR seems to have a poor prognostic value in these patients. A prognostic value of the ELR which was a new biomarker was not determined in sperm retrieval from the TESE procedure.

Keywords: non-obstructive azoospermia, sperm retrieval, testicular sperm extraction, inflammatory markers



Corresponding Author: Belgin Devranoglu, Türkiye
Manuscript Language: English
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