Analysis of Maternal and Fetal Outcomes of Patients Diagnosed with HELLP Syndrome

INTRODUCTION: HELLP syndrome is a multisystem disorder which causes rapid deterioration of maternal and fetal well-being. In this study, we aimed to investigate clinical and labaratory parameters that influencing maternal and perinatal outcomes in addition to relatonship between maternal and perinatal morbidity and mortalitiy in patients which had been diagnosed as HELLP syndrome.
METHODS: In this study, the hospital’s computer system records of 155 patients diagnosed with HELLP syndrome in our clinic between January 2005 and December 2010 were reviewed retrospectively.The demographic characteristics of the patients, maternal and perinatal outcomes and laboratory parameters were analyzed.
RESULTS: The average age of the patients was 29.8 ± 6.9 year, the mean gestational age was 31.4 ± 4.2 week, the mean fetal birth weight was 1672.72±726 gr. Sixty-one percent of patients were multigravida while 39%of patients were primipar. The most common maternal complications were the transfusion requirement in 58 patients (37.4%). We found significant differences between patients who developed at least one complications and no maternal complication with regard to AST, LDH, creatinine, thrombocyte, and total bilirubine levels. Prematurity rate was detected as 83.4%. Maternal mortality was occurred in 12 patients (7.7%).Perinatal mortality was occurred in 9 patients (12%).
DISCUSSION AND CONCLUSION: HELLP syndrome increases maternal-fetal morbidity and mortality. Early diagnosis and appropriate treatment are important in determining the prognosis of HELLP syndrome.