E-ISSN 2757-8062
Volume: 54 Issue: 4 Year: 2023

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Clinical Characteristics and Treatment Outcomes of Pediatric Hodgkin Lymphoma at a Single Center in Turkey [Zeynep Kamil Med J]
Zeynep Kamil Med J. Ahead of Print: ZKMJ-50465 | DOI: 10.14744/zkmj.2023.50465

Clinical Characteristics and Treatment Outcomes of Pediatric Hodgkin Lymphoma at a Single Center in Turkey

Esra Arslantaş1, Ali Aycicek1, Cengiz Bayram1, Sibel Akpınar Tekgündüz1, Sultan Okur Acar1, Züleyha Kadehci2, Deniz Tugcu3, Gül Nihal Özdemir3
1Department of Pediatric Hematology Oncology, Başakşehir Çam ve Sakura City Hospital, İstanbul
2Department of Radiation Oncology, Başakşehir Çam ve Sakura City Hospital, İstanbul
3Department of Pediatric Hematology Oncology, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul

INTRODUCTION: Hodgkin lymphoma (HL) is one of the most curable types of cancer in childhood. This study aims to review the 10 year experience of pediatric Hodgkin lymphoma at a single center in Turkey.


METHODS: This is a retrospective data of 82 pediatric Hodgkin lymphoma patients up to 18 years of age treated between 2009 and 2020.
RESULTS: Median age of the patients was 11 years (range 3-17 years) and 68% of patients were male. Patient numbers by stage were: stage I n=2 (2 %); stage II n=32 (39%); stage III n=35 (43%); and stage IV n=13 (16%). Trend of histopathology was mixed cellularity at 49%. Most common treatment protocol was ABVD (adriamycin, bleomycin, vincristine, doxorubicin) (83%). Majority of patients (n=76, 93%) received involved field Radiotherapy following chemotherapy. Complete remission was achieved with first-line chemotherapy in 90%. The 2-year overall survival (OS) and event-free survival (EFS) rates were 97.5% and 92%, respectively. There was no significant difference in OS and EFS in terms of gender, stage and presence of B symptoms.
DISCUSSION AND CONCLUSION: Our data shows excellent outcome of pediatric Hodgkin lymphoma and results are comparable to that of developed countries. Future studies should focus not only on treatment efficacy but also on identifying the best approaches, in terms of reduced long-term negative side effects.

Keywords: Hodgkin Lymphoma, child, developing country, outcome assessment



Corresponding Author: Esra Arslantaş, Türkiye
Manuscript Language: English
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