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Investigation of the effect of protocol changes in IVF treatment on pregnancy outcomes: A retrospective analysis
Ramazan Murdan1, Enis Özkaya2, Yağmur Minareci31Department of Gynecological Oncology, Hatay Training and Research Hospital, Hatay, Turkey2Department of Gynecology and Obstetrics, Kırklareli University, Kırklareli, Turkey
3Department of Gynecology and Obstetric Oncology, Istanbul University Faculty of Medicine, Istanbul, Turkey
INTRODUCTION: The effect of changing the ovarian stimulation protocol on treatment outcomes after an unsuccessful IVF treatment is still a controversial issue. In this study, we investigated the effect of protocol changes in the second attempt on treatment outcomes in patients who failed in the first attempt.
METHODS: Our study included 60 patients who applied to Zeynep Kamil Training and Research Hospital due to infertility between 01.01.2013 and 01.01.2017, who had previously failed IVF treatment and were trying for the second time. The patients were divided into two groups: those with and without protocol changes in the second trial. The success of these two groups in pregnancy outcomes was compared. Of the 60 patients, 30 were selected from those who underwent protocol changes, while 30 were selected from those who did not undergo protocol changes.
RESULTS: A total of 60 patients between the ages of 22 and 41 were included in our study. Fifty of the 60 patients were primarily infertile, while 10 were secondarily infertile. There was no significant difference in β-hCG positivity in the first and second IVF attempts between the groups with and without protocol changes (p>0.05). There was no clinical pregnancy in either group in the first IVF attempt. In our study, no statistically significant difference was found in clinical pregnancy outcomes in the second attempt between the two groups (p>0.05).
DISCUSSION AND CONCLUSION: In couples whose first IVF attempt was unsuccessful, making a protocol change did not create a statistically significant difference in terms of β-hCG positivity and clinical pregnancy success in the second attempt compared to not making a protocol change.
Manuscript Language: English
