INTRODUCTION: The aim of this study is to investigate the effect of intrauterine insemination (IUI) performed simultaneously with ultrasound detected follicular rupture during biological reproduction window on pregnancy rates in patients with unexplained infertility undergoing ovulation induction (OI) cycles with gonadotropins.
METHODS: Three-hundred and twenty-five patients with unexplained infertility were included in this prospective cohort study, who received recombinant follicular stimulating hormone (75-150 IU/day) or Human Menopausal Gonadotropin (hMG) starting from the 2nd-3rd days of the cycle. IUI was carried out with ultrasonographic monitoring of the follicles. The presence of free fluid within the Douglas pouch, detection of corpus luteum, and/or loss of the dominant follicle were interpreted as follicular rupture. Pregnancy rates with or without follicular rupture were compared after 14 days.
RESULTS: Among those with follicular rupture, the time between administration of recombinant hCG and IUI was significantly longer as compared to those without follicular rupture (p < 0.001). β hCG was positive at 14 days after IUI in 19.01% (31/163) and 13.92% (22/158) of the cases with or without follicular rupture, respectively. The difference in pregnancy rates was not significant (p=0.219).
DISCUSSION AND CONCLUSION: Intrauterine insemination simultaneously performed with ultrasound-detected follicular rupture in ovulation induction cycles with gonadotropins does not increase pregnancy rate.