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Investigation of the Relation with HLA and Esophageal Stricture Formation Following Corrosive Ingestion
Rahşan Özcan1, Erkan Yılmaz2, Günay Can3, Mehmet Eliçevik1, Sebuh Kuruğoğlu4, Ergun Erdoğan11İ.U. Cerrahpaşa Faculty of Medicine, Department of Pediatric Surgery, Istanbul2İ.Ü. Cerrahpaşa Faculty of Medicine, Blood Center, Tissue Type Lab, Istanbul
3İ.Ü. Cerrahpaşa Faculty of Medicine, Department of Public Health, Istanbul
4İ.Ü. Cerrahpaşa Faculty of Medicine, Department of Radiology, Istanbul
INTRODUCTION: Development of esophageal stricture due to corrosive ingestion may be related with different factors. In this study it has been aimed to detect if there is a difference esophageal stricture according to Human Leucocyte Antigen (HLA) type.
METHODS: The patients who were diagnosed with grade 1 or higher esophageal burn has been evaluated retrospectively. Group 1, consisted of 10 cases who have developed esophageal stricture and group 2, consisted of 10 cases who have not. Blood samples were taken from all of the patients for HLA antigen typing and evaluated with statistical analysis.
RESULTS: Mean age was 4.75 (2-10) years. HLA-DRB1’11 was detected more common in group 1 and HLA-A3 in group 2. This difference was neither significant statistically for both.
DISCUSSION AND CONCLUSION: We did not find any significant difference in HLA antigen types between Group 1 and Group 2 about stricture development; however, this early report can predict a guide for further studies. With an increase in case number, we think that more precise information can be acquired about the role of HLA in diagnosis and treatment of esophageal strictures.
Manuscript Language: English
