The relationship between cervical lesions and human papillomavirus subtypes: A retrospective third stage single-center study

INTRODUCTION: Cervical cancer is a preventable disease. Oncogenic HPV subtypes play a very important role in the development of many cancers, especially cervical cancer. In this study, we aimed to investigate the importance of HPV subtypes in cervical lesions.
METHODS: Two hundred seventeen women who were examined in the gynecological oncology outpatient clinic of the hospital, had a positive HPV test, and underwent colposcopic biopsy were retrospectively analyzed. The clinical and examination information of the patients were obtained from the hospital system and files.
RESULTS: Among the HPV subtypes in the patients, HPV subtype 16 was the most common. HPV subtype 16 was found most frequently in H-SIL and L-SIL lesions. In addition, cervical premalignant or malignant lesions were detected in 79 of 217 patients who underwent colposcopic cervical biopsy.
DISCUSSION AND CONCLUSION: Cervical cancer screening methods are one of the few screening methods that have been proven to reduce the mortality and incidence of invasive cancer. The most important risk factor in the etiology of cervical cancer is the HPV virus. As a result, we found that HPV subtype 16 was the most common, and HPV positivity decreased with age.