Zeynep Kamil Med J. 2018; 49(1): 65-71 | DOI: 10.16948/zktipb.367326

Utility of PTEN, MLH1, ARID1A And Β-Catenin, Biomarkers In Endometrial Hyperplasia and Endometrioid Endometrial Carcinoma

Duygu Kösemettin Döver¹, Abdullah Aydýn¹, Serkan Þenol¹, Evrim Bostancý², Çetin Kýlýççý^2
1Medeniyet University, Goztepe Training and Research Hospital, Department of Pathology, Istanbul, Turkey
²Zeynep Kamil Training and Research Hospital, Obstetrics and Gynecology, Istanbul, Turkey

INTRODUCTION: Endometrial carcinomas are divided into two groups roughly: Endometrioid (Type I) and NVon-endometrioid (Type II). The majority of the endometrial carcinomas are of endometrioid type and, this type of carcinoma is associated with hyperplasia which is formed due to unopposed estrogen.In this study, our purpose is to reveal the expression status of the PTEN, MLH1, ARID1A and β-catenin, biomarkers in all types of endometrial hyperplasia (EH) and endometrioid endometrial carcinoma (EC).
METHODS: We conducted a retrospective study with 202 cases including 82 EC cases, 71 simple EH cases without atypia, 16 complex EH cases without atypia, 9 simple atypical EH cases, 24 complex atypical EH cases which were diagnosed at Istanbul Civilization University Göztepe Training and Research Hospital. 10 normal endometrial tissues were used for the purpose of control.
RESULTS: In our study, loss of PTEN ratio was 61%, loss of ARID1A ratio was 52,4%, loss of MLH1 ratio was 40,2% in patients with EC. These ratios were 87,5%, 41,7%, 20,8%, respectively in patients with atypical complex EH and 12,7%; 4,2%; 1,4% in patients with simple EH without atypia.
DISCUSSION AND CONCLUSION: In the light of these findings it has been demonstrated that PTEN, ARID1A and MLH1 have a role in the transition from simple EH to atypical complex EH, and also MLH1 has a role in the transition from aytpical complex EH to EC.

Keywords: endometrial hyperplasia, endometrioid endometrial carcinoma, PTEN, MLH1, ARID1A, β, -catenin

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