E-ISSN 2757-8062
Volume: 52 Issue: 4 Year: 2021

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Frequency of glucose-6-phosphate dehydrogenase enzyme (G6PD) deficiency in newborns with prolonged jaundice [Zeynep Kamil Med J]
Zeynep Kamil Med J. Ahead of Print: ZKMJ-88709 | DOI: 10.14744/zkmj.2021.88709

Frequency of glucose-6-phosphate dehydrogenase enzyme (G6PD) deficiency in newborns with prolonged jaundice

Hüseyin Taştanoğlu1, Rabia Gönül Sezer Yamanel2, Abdulkadir Bozaykut2
1Sivas Zara State Hospital, Pediatric Clinic, Sivas, Turkey
2University of Health Sciences,Zeynep Kamil Women And Children Diseases Training And Research Hospital,Department Of Pediatrics,i̇stanbul, Turkey

INTRODUCTION: The aim of the study is to determine the frequency of glucose-6-phosphate dehydrogenase enzyme (G6PD) deficiency in preterm and term newborns with prolonged jaundice.
METHODS: 670 preterm and term newborns who applied to Zeynep Kamil Training and Research Hospital Pediatric Health Polyclinic with neonatal jaundice between 01.01.2014 and 01.04.2018 were retrospectively screened and include in the study. Birth weight, sex, gestational week, postnatal age, gender, phototherapy, need for exchange transfusion were recorded. Laboratory evaluations included blood group typing of mother and newborn, serum total and direct bilirubin levels, reticulocyte count, erythrocyte G6PD level. SPSS 22.0 was used as an evaluation program.
RESULTS: G6PD enzyme level was detected in 374 (55.8%) of the cases. Enzyme deficiency was detected in 12 (3.2%) cases. There was no statistically significant difference between G6PD-deficient group and G6PD-normal group in terms of all parameters except TBIL level. There was no case in whom exchange transfusion was performed with high bilirubin values. However, phototherapy was applied in 231 cases due to high bilirubin levels. It was determined that there was no need for phototherapy in all cases with G6PD levels.
DISCUSSION AND CONCLUSION: G6PD enzyme deficiency should be investigated in patients with prolonged jaundice.

Keywords: Glucose-6-phosphate dehydrogenase enzyme (G6PD) deficiency, prolonged jaundice, hyperbilirubinemia.



Corresponding Author: Hüseyin Taştanoğlu, Türkiye
Manuscript Language: English
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