INTRODUCTION: The objective of this study is to investigate the relationships between human seminal leptin levels and semen parameters
METHODS: Study groups include 30 males with oligoasthenoteratozoospermia and 30 males who have normal semen parameters. Leptin and DNA fragmentation levels were investigated in both groups, along with a variety of semen parameters including sperm count and motility
RESULTS: In comparison with the normal males, sperm count and motility have decreased significantly in fertile patients: 6,40+4,29(x106ml), %38,63+ 14,92 (p<0.0001). DNA fragmentation levels were found as 21,00+8,23 % and 38,43+14,23% in normal and patient groups respectively. Seminal leptin levels were 347,58+111,13 ng/ml in the normal group. Among infertile groups, no significant difference was observed regarding the relationships between seminal leptin levels and age, volume, sperm count and motility
DISCUSSION AND CONCLUSION: In our study it was demonstrated that, serum leptin levels decrease in the oligoasthenoteratozoospermic infertile males, while there is not a significant realtion with the motility of sperm. In order to use seminal leptin levels as a diagnostic tool more extensive studies are needed.