E-ISSN 2757-8062
Volume: 53 Issue: 2 Year: 2022

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The Relationship of Seminal Leptin Levels with Semen Parameters and Dna Fragmentation [Zeynep Kamil Med J]
Zeynep Kamil Med J. 2017; 48(2): 40-45

The Relationship of Seminal Leptin Levels with Semen Parameters and Dna Fragmentation

Şule Ayla1, Ilknur Keskin1, Tuba Varlı Yelke2, Tuğçe Önel1, Serçin Karahüseyinoğlu3
1Istanbul Medipol University, Faculty of Medicine, Department of Basic Medical Sciences, Histology and Embryology Department
2Medipol Mega Hospital, Istanbul
3Koç University, Istanbul

INTRODUCTION: The objective of this study is to investigate the relationships between human seminal leptin levels and semen parameters
METHODS: Study groups include 30 males with oligoasthenoteratozoospermia and 30 males who have normal semen parameters. Leptin and DNA fragmentation levels were investigated in both groups, along with a variety of semen parameters including sperm count and motility
RESULTS: In comparison with the normal males, sperm count and motility have decreased significantly in fertile patients: 6,40+4,29(x106ml), %38,63+ 14,92 (p<0.0001). DNA fragmentation levels were found as 21,00+8,23 % and 38,43+14,23% in normal and patient groups respectively. Seminal leptin levels were 347,58+111,13 ng/ml in the normal group. Among infertile groups, no significant difference was observed regarding the relationships between seminal leptin levels and age, volume, sperm count and motility
DISCUSSION AND CONCLUSION: In our study it was demonstrated that, serum leptin levels decrease in the oligoasthenoteratozoospermic infertile males, while there is not a significant realtion with the motility of sperm. In order to use seminal leptin levels as a diagnostic tool more extensive studies are needed.

Keywords: leptin, oligoasthenoteratozoospermia, male infertility

Şule Ayla, Ilknur Keskin, Tuba Varlı Yelke, Tuğçe Önel, Serçin Karahüseyinoğlu. The Relationship of Seminal Leptin Levels with Semen Parameters and Dna Fragmentation. Zeynep Kamil Med J. 2017; 48(2): 40-45

Corresponding Author: Şule Ayla, Türkiye
Manuscript Language: English
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