The Role of Biochemical Markers of First Trimester Trisomy Screening Test In The Predictıon of Gestational Diabetes Mellitus

INTRODUCTION: To investigate the potential advantage of routinely examined biochemical markers; PAPP-A (pregnancy related plasma protein A) and ßHCG values, in the first trimester screening test for the screening and early diagnosis of gestational diabetes mellitus (GDM) disease that occured in the following weeks of pregnancy without bringing any additional cost.
METHODS: This study was designed as a retrospective cohort study. In this study singleton pregnancies were included whose first trimester trisomy screening tests were examined in our hospital and also deliviries of them took place in our hospital with the routine pregnancy follow up between January 2014 – December 2016. The pregnancies were divided into two groups as GDM and control group. The functional role of biochemical markers ( PAPP-A (MoM), ßhcg (MoM)) in the first trimester screening test were investigated for early diagnosis of GDM which appeared in the later gestational weeks of pregnancy
RESULTS: In the GDM group; maternal age, the number of pregnancies, parity, abort and living children were found significantly
high, according to the control group (p<0.05). Statistically significant difference was not observed between PAPP-A (MoM), ßhcg (MoM), NT (mm) ve NT (MoM), gestational week of delivery, birth infant weight, APGAR 1.minute and APGAR 5.minute in the GDM group.
DISCUSSION AND CONCLUSION: No statistically significant relationship was established between biochemical markers of first trimester screening test and GDM in this study. However, more patients and carefully planned prospective studies are needed in this subject.