Calcium ionophore enhances blastocyst formation, embryo quality, and live birth delivery rates in patients with previous IVF failures

INTRODUCTION: The objective of the study was to evaluate the impact of artificial oocyte activation (AOA) with calcium ionophore (A23187) on in vitro fertilization outcomes of patients with previous history of cycle cancellations due to arrested embryos before formation of day 5 blastocysts.
METHODS: This retrospective study was conducted by evaluating records of patients that admitted for in vitro fertilization between 2013 and 2021. Patients with the previous history of developmental arrest in whole embryo cohort without fertilization failure were included in the study. Cycle outcomes of women with and without AOA were compared.
RESULTS: This retrospective study was conducted by evaluating records of patients that admitted for in vitro fertilization between 2013 and 2021. Patients with the previous history of developmental arrest in whole embryo cohort without fertilization failure were included in the study. Cycle outcomes of women with and without AOA were compared.
DISCUSSION AND CONCLUSION: AOA with A23187 appears to improve progression to blastocyst rates, embryo quality, clinical pregnancy rates, and live birth delivery rates in women with a previous history of complete embryo development arrest before formation of day 5 blastocysts.