E-ISSN 2757-8062
Volume : Issue : Year : 2022

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Zeynep Kamil Medical Journal
Karyotype Analysis of Products of Conception in Patients with Recurrent Pregnancy Loss [Zeynep Kamil Med J]
Zeynep Kamil Med J. Ahead of Print: ZKMJ-34735

Karyotype Analysis of Products of Conception in Patients with Recurrent Pregnancy Loss

Yeşim Özdemir1, Resul Arısoy2, Fatih Şanlıkan2, Koray Özbay2, Altuğ Semiz2
1Genetic Diseases Assessment Center, Şişli Memorial Hospital, İstanbul, Turkey
2Department of Obstetrics and Gynecology, Şişli Memorial Hospital, İstanbul, Turkey

INTRODUCTION: The purpose of this study is to discuss the results of products of conception karyotype analysis in cases with recurrent pregnancy loss.
METHODS: The data of the cases evaluated with the diagnosis of recurrent pregnancy loss were retrospectively obtained and the results were examined (n=485). Among them, 135 cases with karyotype analysis were included in the study. Maternal age, gestational week and karyotype analysis results were recorded (n=129). Cases between 6-14 weeks of age were included in the study. Maternal age, gestational week and karyotype analysis results of cases with recurrent pregnancy loss between 6-14 weeks of gestation were recorded as data. Genetic analysis of POC was made with conventional cytogenetic techniques.
RESULTS: 135 cases diagnosed with RPL were included in the study. Mean maternal age was 34.43±5.41 years and mean gestational age was 8.36 ±1.58 weeks. Abnormal karyotype was detected in 40 cases (40/129, 31%). Karyotype analysis was normal in 89 cases and among these, two fetuses had 46,XX,9qh+ polymorphism. In cases with abnormal karyotype, maternal age was found to be more advanced compared to euploid karyotypes (35.97 ±5.31 vs 33.57±5.31, p: 0.0188). Again, in male fetuses (17/35), when compared to females (23/83), significantly more abnormal karyotypes were detected (p: 0.048).
DISCUSSION AND CONCLUSION: The frequency of abnormal karyotype in RPL cases was 31%, and the most common abnormality was autosomomal trisomies (62.5%). Trisomy 22 was the most common of the trisomies (24%). We also emphasize that the frequency of abnormal karyotype increases with advanced maternal age, according to our results.

Keywords: Recurrent pregnancy loss, karyotype analysis, genetics



Corresponding Author: Fatih Şanlıkan, Türkiye
Manuscript Language: English
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