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Zeynep Kamil Medical Journal
Can systemic inflammatory markers predict sperm retrieval with the micro-TESE procedure in patients with non-obstructive azoospermia? A tertiary IVF center experience [Zeynep Kamil Med J]
Zeynep Kamil Med J. 2022; 53(4): 176-182 | DOI: 10.14744/zkmj.2022.46704

Can systemic inflammatory markers predict sperm retrieval with the micro-TESE procedure in patients with non-obstructive azoospermia? A tertiary IVF center experience

Belgin Devranoğlu1, Ali Aras2, Gökşen Derya Reis Köse3, Elif Tozkır1, Pınar Kumru1, Enis Özkaya1, Ilhan Şanverdi1, Ebru Çöğendez1, Nurullah Peker4
1Department of Obstetrics and Gynecology, University of Health Sciences, Türkiye. Zeynep Kamil Maternity and Children’s Training and Research Hospital, İstanbul, Türkiye
2Department of Urology, University of Health Sciences, Türkiye. Zeynep Kamil Maternity and Children’s Training and Research Hospital, İstanbul, Türkiye
3Department of Histology and Embryology, University of Health Sciences, Türkiye. Zeynep Kamil Maternity and Children’s Training and Research Hospital, İstanbul, Türkiye
4Department of Obstetrics and Gynecology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye

INTRODUCTION: We aim to investigate the relationship between the pro-inflammatory markers and sperm retrieval (SR) in microdissection testicular sperm extraction (micro-TESE) procedure in patients with non-obstructive azoospermia (NOA).
METHODS: This retrospective study was conducted with 318 patients who applied to our in vitro fertilization Unit between April 2017 and December 2020 and underwent micro-TESE for NOA. Patients with (Group 1) and without (Group 2) sperm retrieved were compared in terms of age, infertility duration, body mass index (BMI), hormone profile, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-eosinophil ratio (MER), platelet-to-lymphocyte ratio (PLR), and a new marker of eosinophil-to-lymphocyte ratio (ELR).
RESULTS: SR from the micro-TESE procedure was achieved in 183 (57.5%) of 318 patients. Testicular tissue biopsies were performed simultaneously in all cases. There was no statistically significant difference between the groups concerning BMI. When the groups were compared regarding the pro-inflammatory markers, while the NLR, MER, and PLR were found to be statistically higher in Group 2 cases; ELR was similar among groups.
DISCUSSION AND CONCLUSION: The MER, NLR, and PLR were determined to be associated with negative micro-TESE results. Particularly PLR seems to have a poor prognostic value in these patients. A prognostic value of the ELR which was a new biomarker was not determined in SR from the TESE procedure.

Keywords: In vitro fertilization, inflammatory markers, non-obstructive azoospermia, sperm retrieval, testicular sperm extraction.

Belgin Devranoğlu, Ali Aras, Gökşen Derya Reis Köse, Elif Tozkır, Pınar Kumru, Enis Özkaya, Ilhan Şanverdi, Ebru Çöğendez, Nurullah Peker. Can systemic inflammatory markers predict sperm retrieval with the micro-TESE procedure in patients with non-obstructive azoospermia? A tertiary IVF center experience. Zeynep Kamil Med J. 2022; 53(4): 176-182

Corresponding Author: Belgin Devranoğlu, Türkiye
Manuscript Language: English
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