E-ISSN 2757-8062
Volume : Issue : Year : 2023

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Zeynep Kamil Medical Journal
Evaluation of Cardiovascular Risk Marker in Patients with Polycystic Ovary Syndrome: Homocysteine [Zeynep Kamil Med J]
Zeynep Kamil Med J. Ahead of Print: ZKMJ-57614 | DOI: 10.14744/zkmj.2023.57614

Evaluation of Cardiovascular Risk Marker in Patients with Polycystic Ovary Syndrome: Homocysteine

Caner Topaloğlu1, Cansu Önal kanbaş2, Tamer Topaloğlu2
1Department Of Cardiology, Izmir University Of Economics, Izmir, Turkey
2Department Of Gynecology And Obstetrics, Kartal Lutfi Kırdar City Hospital, Istanbul, Turkey

INTRODUCTION: The aims of the study were to investigate homocysteine (Hcy) levels in polycystic ovary syndrome (PCOS) patients without insulin resistance (IR) and metabolic syndrome (MS).
METHODS: This retrospective study involves 64 patients between 18-35 years who applied to the tertiary clinic between March 2022 and March 2023. A total of 32 PCOS without IR and MS and 32 healty women were enrolled in the study. All participants performed history, clinical physical examination, gynecological ultrasonographic evaluation and laboratory tests. Laboratory screening tests including follicle stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (T), free T, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), low density lipoprotein (LDL) were performed. Normal insulin sensitivity was defined on the basis of fasting serum glucose, fasting insulin level, serum insulin response to oral glucose tolerance test and homeostatic model of insulin resistance.
RESULTS: There were no differences in terms of age, systolic and diastolic blood pressure, FSH, LH, total T, free T, SHBG, DHEAS, LDL between the groups. PCOS patients had increased Hcy, waist to hip ratio (WHR), body mass index (BMI) compared to the control group. Hcy was positively correlated with WHR, BMI. A strong correlation was found between Hcy and PCOS.
DISCUSSION AND CONCLUSION: Elevated Hcy is associated with cardiovascular risk factors in PCOS without IR and MS.

Keywords: polycystic ovary syndrome, homocysteine, cardiovascular risk factor

Corresponding Author: Caner Topaloğlu, Türkiye
Manuscript Language: English
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