Chorioangiomas are the most common benign tumors of placenta. In our case, a 30 years old woman, gravida 2, para 1 at 22 weeks of gestation was referred to our Perinatology Department due to high levels of maternal serum alpha-fetoprotein (MSAFP). Doppler ultrasonography showed that the placenta was attached to left-posterior wall of uterus and a 40x38 mm solid, vascularized mass was present in it. No fetal abnormality was detected. Patient was followed with preliminary diagnose of placental chorioangioma and at 32 weeks of gestation, it was detected that the size of the mass was 64x54 mm and accompanied by polihydroamnios. Patient was
hospitalized because of abnormal umbilical artery Doppler finding as absence of end diastolic flow. After applying corticosteroids and completion of fetal lung maturation, a caesarean section was performed due to previous cesarean delivery history.
Diagnose of placental choriangioma was confirmed after pathological examination. As a result, we suggest; detailed evaluation of
placenta should be performed in patients with elevated MSAFP levels. Patients with preliminary diagnose of placental chorioangioma should be followed closely for possible fetal and maternal complications.