E-ISSN 2757-8062
Volume : 44 Issue : 3 Year : 2022

Quick Search




Zeynep Kamil Medical Journal
Prenatal Treatment of Fetal Goitrous Hypothyroidism by Intraamniotic Thyroxine [Zeynep Kamil Med J]
Zeynep Kamil Med J. 2013; 44(3): 155-158

Prenatal Treatment of Fetal Goitrous Hypothyroidism by Intraamniotic Thyroxine

Cihangir Yılanlıoglu1, Altuğ Semiz1, Yaşam Kemal Akpak2
1Fetal Medicine and Perinatology Unit, Memorial Hospital, Istanbul, Turkey
2Department of Obstetrics and Gynecology, Sarıkamış Military Hospital, Kars, Turkey.

We present the management of a case of fetal goitrous hypothyroidism (FGH) referred to our centre on completion of the 31th week with a view to prenatal treatment. The fetus displayed an anterior neck mass recognizable as thyroid by location and texture. The mother had normal thyroid function tests and no antithyroid antibodies. A cordocentesis was performed to reveal hypothyroid status, also checking the fetal karyotype which was a normal male. Intraamniotic injections of L-thyroxine 500 μg were carried out weekly. After six applications of the dose the pregnancy reached 38+5 weeks when normal delivery ensued, the newborn presenting a euthyroid status. He grew up to a healthy boy, now seven years of age, with completely normal motor and intellectual development. The rationale behind diagnosis, prenatal treatment and appropriateness of such management is discussed in this article.

Keywords: Congenital Hypothyroidism, Fetal Goiter, Fetal Therapy, Prenatal Diagnosis, Cordocentesis, Amniocentesis.

Prenatal Treatment of Fetal Goitrous Hypothyroidism by Intraamniotic Thyroxine

Cihangir Yılanlıoglu1, Altuğ Semiz1, Yaşam Kemal Akpak2
1Memorial Hastanesi Fetal Tıp ve Perinatoloji Ünitesi, İstanbul, Türkiye
2Sarıkamış Askeri Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, Kars, Türkiye


Cihangir Yılanlıoglu, Altuğ Semiz, Yaşam Kemal Akpak. Prenatal Treatment of Fetal Goitrous Hypothyroidism by Intraamniotic Thyroxine. Zeynep Kamil Med J. 2013; 44(3): 155-158

Corresponding Author: Yaşam Kemal Akpak, Türkiye
Manuscript Language: Turkish
LookUs & Online Makale